Sometimes the woman can release more eggs at the same time especially with drugs for fertility treatment. If you have two eggs you will need two spermatozoa, and they could be from different donors, so yes the woman could have twins from 2 men. The classic case in American medical literature was recorded in by John Archer, the first doctor to receive a medical degree in the United States. A white woman who had intercourse with both a white man and a black man within a short period of time subsequently gave birth to twins—one white, one mulatto. There have been other reported cases since then.